【摘要】 本文应用单克隆抗体OC₁₂₅对妇科良性肿瘤11例、恶性肿瘤11例、宫颈癌19例、术后或化疗后的妇科恶性肿瘤17例及正常妇女19例,进行了血清卵巢癌相关抗原(CA₁₂₅)的免疫放射分析（IRMA）,以<65U/ml为正常值。其结果正常妇女(CA₁₂₅)值均正常,卵巢良性及恶性肿瘤患者各升高13％和78％;宫颈癌患者16％升高。提示血清(CA₁₂₅)测定作为卵巢癌综合判断指标具有一定价值。本文对术后或化疗后妇科恶性肿瘤17例的(CA₁₂₅)值进行了观察,凡病情恶化、复发或转移者(CA₁₂₅)值升高,缓解稳定者(CA₁₂₅)值正常。说明血清(CA₁₂₅)值可以作为妇科恶性肿瘤病情监测的一项指标。更多还原

【Abstract】 The sera frcm 58 women (11 with benign gynecologic tumors, 19 cervical carci- nomas, 11 other malignant tumors, 17 malignant tumors after operation or chemother- apy) were determined for an ovarian cancer associated antigen (CA 125) by mono- clonal antibody OC 125. Control group consisted of 19 normal women. The results showed that there was no one scored as positive in healthy women and that CA 125 positive rates in patients with benign ovarian tumor, malignant tumor and cervical carcinoma were 13%, 78% and 16% respectively (value of CA 125 less than 65u/ml scored as negative). During the follow-up, it was found that in 17 patients with cancer after operation or chemotherapy, CA 125 was elevated when deterioration, relapse or metastasis occurred but was not elevated when patient’s condition was stable. Thus, CA 125 may be used in monitoring the course of disease.更多还原