【摘要】 本文报道垂体外照射后肢端肥大症伴糖代谢紊乱者23/67例,对其生长激素和胰岛素分泌失常进行了研究。发现67例患者血清GH水平均较对照组升高且不被高血糖抑制,其中仅1/3件糖代谢紊乱,而伴糖代谢紊乱者均显示萄萄糖刺激后,初期胰岛素分泌低下和/或释放高峰延迟。对其发生机理进行探讨。更多还原

【Abstract】 In this paper, an abnormal secretion of plasma human growth hormone (hGH) and insulin in 67 acromegalic patients had been previously treated by external pituitary radiaticn were studied. All subjects, following an overnight fast,a standard 100 g oral glucose tolerance test were performed and venous blocd samples were taken at 0、30、60、120 and 180 min. They were measured for blood glucose, plasma insulin and hGH.The results of this study have shown that,of the 67 subjects,23 cases had an abnormal glucose tolerance(34.32%).Diabetes was detected in 17 cases(23.37%) and 6 patients had decreased glucose tolerance(8.69%). In all, hGH levels were consistantly above 5 ng/ml and were not suppressed after an oral glucose lead. In these patients, however, about cne-third had abnormal glucose tolerance. Low plasma insulin response to gluccse and that of the releasing was later were evident in them than the normal luccse tolerance and a healthy control group. In addition, the mechanism of the abnormal secreticn of LH and insulin were disscussed.更多还原