【摘要】 应用高分辨染色体技术,分析了人体肝癌细胞系SMMC-7721染色体核型。分析表明SMMC-7721细胞系核型染色体众数为54～73条,各核型中正常染色体55～65条,异常染色体7～15条,其中可识别其结构的标记染色体13条,包括缺失、易位及等臂染色体。在每个核型中X染色体均为2N,Y染色体为N。这些染色体的数目异常与结构畸变,对认识肝细胞的转化、恶变提供了细胞遗传学基础。更多还原

【Abstract】 An analysis of the karyotype of SMMC-7721 cell line from human hepatoma was performed, using the high resoluticn chrcmcscmal technique. It manifested that the mode of the karyotype of SMMC-7721 was from 52～73. There were normal and abnormal chromosomes respectively, about 55～65 ard 7～15 in each karyotype. Among the abnormal chrcmcscmes, 13 were distinguishable marker chromosomes, including deleticn, translccaticn and isechromosome. In each karyotype, X chromosomes. were 2N and Y chromosomes Were 1N. The aberration of number and structure of these chromosomes was significant. It is useful to research the transformation of liver cell further and it provides the cytogenetic fundation of malignancy.更多还原