【摘要】 <正> 甲基硫酸新斯的明,化学名为甲基硫酸[(3—羟苯基)三甲基铵)二甲氨基甲酸酯,为抗胆碱酯酶药。我国药典(1985年版)采用蒸馏容量法测定其含量,该法操作烦琐、费时,误差较大。本文报道了甲基硫酸新斯的明PVC膜电极的研制及其应用。用该电极测定甲基硫酸更多还原

【Abstract】 The PVC membrane selective electrode was prepared with ion-pair complex sodium tetraphenyl boron and neostigmine methylsulfate——as electroactive material. The electrode showed a Nernstian response ranging from 10^-1mol/L to 10^-5mol/L with the detective limit 7.2×10^-6mol/L. Response time is short and the stability and reproducibility of the electrode are good. By using the electrode, the recovery in the determination of pure filcilin was 99.7% with a variation coefficient of 0.86%. The results in the determination of pharmaceutical injections were found to be comparable with those obtained by using the pharmacopeia method.更多还原