【摘要】 用光镜和电镜技术,动态地观察了家兔实验性压力性左心室肥厚心肌细胞形态结构的定性变化,着重于超微结构方面,试图从形态学角度探讨心肌肥厚发生、发展的某些规律。更多还原

【Abstract】 Left ventricular hypertrophy has been induced 3,5 and 6 weeks after banding the ascending aorta of rabbits (group H-1, H-2 and H-3). Numerous small mitochondria, condensation, division and budding of mitochondria observed in group H-1 were interpreted as overactivity of energy metabolism and hyperplasia of mitochondria in the left ventricular cardioeyte. In group H-2, the hyperplasia and damage of mitoehondria coexisted, which may reflect a decreased energy metabolism in the cardiocyte. In addition, the expanded Z-band and intercalated disc folds may be evidences of the synthesis of new myofilaments. Swelling, lysis and vacuolization of many mitochondria in group H-3 resulted from decreased energy metabolism and anoxia of the cardiocytes. Nevertheless, larger nuclei with zigzag appearance, numerous interchromatin ranules were evidences of active synthesis of protein. The intraeytoplasmic junctions appeared in this study may be related to the synthesis of new myofilaments, or related to the increase of surface area of hypertrophied cardioeytes.更多还原