【摘要】 在大鼠分娩次日,用5,6-DHT选择性损毁中枢5-HT能神经元,使下丘脑5-HT含量显著降低,吮乳诱发的催乳素分泌受到抑制,乳汁分泌显著减少,仔鼠生长迟缓。在泌乳已正常进行四天后作同样处理,仍有相似结果。提示5-HT参与泌乳的发动及维持。对5-HT的作用与催乳素和催产素的关系进行了讨论。更多还原

【Abstract】 Selective damaging of central serotoninergic neurons with 5,6-dihydroxytryptamine in rats on post-partum day 1 resulted in significant reduction of hypothalamic serotonin content, re- markable attenuation of suckling-induced prolactin response, considerable decrease of milk yield and retarded growth of the pups. Same treatment after establishment of normal lactation on post-partum day 4 got similar results. These results suggested that central serotoninergic system is involved in both initiation and maintenance of lactation of the rats. The relationship between serotonin effect and prolactin or oxytocin was discussed.更多还原