【摘要】 给大白鼠喂饲克山病病区粮,并分别向病区粮加维生素 E 和硒,观察亚硝酸钠急性中毒情况下各组大鼠血清甲状腺激素的变化。结果表明,亚硝酸钠可干扰甲状腺正常功能,维生素 E 和硒可不同程度地减轻亚硝酸钠的这种毒性作用。提出除低硒外,亚硝酸盐过多及维生素 E 缺乏在克山病发病中可能有重要作用,需要重视。更多还原

【Abstract】 Under acute NaNO₂ poisoning,the changes of serum thyroid hormone ofrats kept on diet with grains obtained from the endemic region of Keshandisease and the same diet besides adding vitamin E or selenium respectivelywere investigated.By gavage of NaNo₂,the normal thyroid function of the rats kept on grainsfrom the endemic region was disturbed.Vitamin E or Selenium supplementationdepressed the toxic action of NaNo₂ in varying degrees.It is suggested thatthe role of excess of nitrite and poor Vitamin E in occurrence of Keshan dis-ease should be paid more attention,in addition to selenium deficiency.更多还原