【摘要】 本文报告“水源高碘地方性甲状腺肿并发甲状腺机能亢进”（以下简称水源高碘甲肿甲亢）,在高碘地甲肿患者中检出率高达7.76%。临床上有甲状腺Ⅱ°—Ⅲ°弥漫性肿大,有典型甲亢的症状和体征。甲状腺吸¹³¹碘率较当地居民明显增高,血清 T₃、T₄偏高,但 TSH 基本正常,有的甚至偏低,T₃抑制试验不抑制,有的 TGAb、TMAb 为阳性,有的 TPO （过氧化物酶活性）增高。病理检查:具有巨滤泡性胶样甲状腺肿和甲状腺机能亢进两组病理学和超微结构特征。更多还原

【Abstract】 11 cases of hyperthyroidism were found in a survey of iodine goiter,whichhad been prevalent in certain areas in Shandong province.A rate of 7.76%was obtained from a separate epidemiologic study,the local inhabitants rec-eived a high iodine intake through water.The clinical picture was consistentwith manifestation of hyperthyroidism,a history of thyroid enlargement Ⅱ-Ⅲprior to the onset of hyperthyroidism was usually present。RAIU was marke-dly elevated as compared with average local level.There was slight increaseof serum total T₃ T₄,but serum TSH was within normal limit.T₃ suppress-ion test was negative.Serum TGAb、TMAb appeared positive in some cases.Thyroid peroxidase activity showed a marked increase in some cases Pa-thological and electron-microscope study of the specimens revealed biologicalfeature characteristic of hyperthyroidism as well as feature of colloid goiter.更多还原