【摘要】 漏芦蜕皮甾酮(RUE)是从祁州漏芦根中提取的一种植源性蜕皮激素。本文以2％高脂血清培养家兔主动脉平滑肌细胞,形成细胞损伤;采用TBA萤光法,放射自显影和电镜,观察RUE与维生素E对受损细胞的影响。结果发现二种药物作用相似,均使细胞增生,细胞内过氧化脂含量降低,胞浆脂滴缩小、减少,未发现细胞死亡。由此认为RUE可能因具有抗脂质过氧化作用,保护了平滑肌细胞结构完整,从而显示出抗动脉粥样硬化的作用。更多还原

【Abstract】 RUE is a plant ecdysone,a major component extracted from Rhaponticum Uniflorum.The aortic smooth muscle cells (SMC) were injured by culturing in 2％HLS (hyperlipemic serum).The action of RUE and vitamin E on injured SMC were assayed with TBA fluorescence technique,autoradiography and electron microscopy.It was found that RUE showed similar effects on cells as that of control drug,vitamin E,such as the activation of SMC proliferation,reduction of Lpo (Iipid peroxide) content and maintaining ultrastructural integrity of SMC.Considering that RUE might be able to fnhibit lipid peroxidation thus avoiding degenerative changes of SMC and to keep its fine structure well,we think that may play an important role in the anti-atherosclerosis mechanism of Rhaponticum Uniflorum atherosclerosis,lipid peroxide,hyperlipemic serum更多还原