【摘要】 用麻醉开胸狗,观察了左冠状动脉前降支(LAD)结扎后2小时内,左,右心室舒缩性能、泵功能及肺循环压力和阻力的动态变化,并分析其相互关系。结扎LAD所造成的心肌缺血范围占左心室(LV)重量的35.2±1.4%。LAD结扎后,依次出现LV舒缩性能、肺动脉压、左、右心室泵功能、LV收缩性船、右心室(RV)舒张性能和肺血管阻力的改变,而RV收缩性能则无明显变化。结果表明,较大范围的LV心肌梗塞(MI)早期,LV功能降低可直接导致RV舒张性能降低,还可直接和通过肺循环压力和阻力升高间接使RV泵功能降低。但对RV收缩性能无明显影响。因子分析提示,LV收缩性能与两心室泵功能的改变是LVMI后心功能改变的主要方面;依次为两心室舒张性能和肺循环功能的改变。更多还原

【Abstract】 In anesthetized and thoracotomized dogs the dynamic changes of biventricular contractility, relaxation, pump function, pulmonary circulatory pressure and resistance were observed and the relations among them were analysed in 2 hours after left anterior descending coronary artery (LAD) ligation. The myocardial ischemic size made by LAD ligation amounted to 35.2±1.4% of left ventricular (LV) mass. After LAD ligation, the decrease of LV relaxation and increase of pulmonary artery pressure happened at first. Then left and right ventricular pump function, LV contractility and right ventricular (RV) relaxation decreased in turn. And pulmonapy vascular resistance increased by a big margin at last. Biventricular pump functions decreased more obviously while pulmonary vascular resistance increased. RV contractility did not change significantly.The results show that the decrease of LV function results in the decrease of RV relaxation directly and RV pump function directly and indirectly by means of increased pulmonary circulatory pressure and resistance but do not effect on RV contractility during early stage of LV myocardial infarction (MI). Factor analysis indicates that the alterations of LV contractility and biventricular pump function are very consistent and play a leading role in the changes of cardiac function after LVMI, the alterations of biventricular relaxation and pulmonary circulatory function take second place in due order.更多还原