【摘要】 用薄层聚丙烯酰胺凝胶等电聚焦方法对62例全身性红斑狼疮(SLE)、61例寻常型银屑病(PV)及17例胰岛素依赖性糖尿病(IDDM)病人补体第二途径成份B因子SS型的亚型分布及基因频率进行了检测。结果表明,SLB病人BfSS亚基因频率分别为,S_A0.516,S_B0.484;PV为:S_A0.492,S_B0.508,IDDM为:S_A0.676,S_B0.324。与正常人(S_A0.414,S_B0.586)比较,三种疾病的S_A亚基因频率均有不同程度的增高,并伴有S_B亚基因频率的降低。统计结果表明,IDDM与正常人的差异显著(P<0.01),SLE次之(P<0.05),PV不著(P>0.1)。此外,这三种疾病病人BfS_A-S_A亚型的表型频率(分别为30.6%、31.1%和41.1%)都显著高于正常19.3%),统计学表明差异均显著(P<0.05)。更多还原

【Abstract】 The subtypes of BfSS phenotype in patients with SLE, PV and IDDM were investigated using the isoelectrofocusinq technigue; Subgene frequencies for 62 SLE patients with BfSS phenotype are 0.516 for S_A. and 0.484 for S_B. The 61 PV patients with BfSS phenotype are 0.492 for S_A, and 0.508 for S_B. The 17 IDDM patients with BfSS phenotype are 0.676 for S_A, and 0.324 for S_B. Significant increase tn subgene frequencies of BfS_A in patients with IDDM and SLE were found in comparison with that In the controls. In addition, increase in BfS_A-S_A phenotype frequencies were observed for SLE, PV and IDDM. These results suggest that there are some positive association with BfSA in these diseases.更多还原