【摘要】 本文证明金黄地鼠对于流行性出血热病毒包括家鼠型和野鼠型毒株均敏感。除口饲外,多途径接种均可使地鼠感染。流行性出血热病毒浙5株10001D₅₀接种3周龄地鼠,五天后即可在肺、脾、肠、肝等多种组织中检出病害抗原,至8—10天达最峰,其中肺最强,抗原持续时间至少50天。接种病毒后10天左右,可在血中检出抗体,后缓慢上升,至第50天达1:1280—1:5120。乳鼠感染EHF病毒后可引起全身播散性感染,病毒抗原可在全身软组织中找到。乳鼠感染强毒株可发病致死,但幼鼠和成鼠不表现症状为健康带毒者。更多还原

【Abstract】 It was shown in our study the hamster is susceptible to Epidemic Hemor- rhagic Fever Virus（EHFV） including the wild-mouse type(strains Z₃, Z₄, Z₅, Z₁₀, 76—118) and the house-rat type(strains Z₂₆, R₂₂, SR-11,Z₃₀,Z₃₄). The hamster was successfully infected intramuscularly, intraperitoneally, subcutaneously and intrapulmonaryly or intracerebrally （suckling hamster） but not orally. EHFV antigen appeared in lung 5 days after inoculation of EHFV strain Z₅ and persisted for at least 50 days.EHFV antigen was detected in adult hamster in various organs including lung, liver, kidney, spleen and intestine, especially in lung, the suckling hamsters have resulted in disseminated infection, viral antigen was found in soft tissue of the whole body such as brain, muscle, skin, tail, ear etco besides lung, liver, kidney, spleen, heart. The appearance of antibody to EHFV in hamsters is 10—12 days after inocultion of EHFV, the 1: 5120 titres were observed at the 7th week. The adult hamsters inoculated with EHFV showed no overt disease, but EHFV which passage in the brain of suckling mice causes disease and death among suckling hamsters.更多还原