【摘要】 采用含胆固醇(1％)和胆盐(0.25％)的合成饲料喂饲SD大鼠12周,诱发高胆固醇血症的同时,加入含84.8％葡甘露聚糖的魔芋精粉,三个实验组加入量占饲料重分别为2.5、5.0、10.0％,观察降低血清和肝胆固醇作用。经酶法测定胆固醇含量和肝组织病理学检查结果表明,魔芋多糖对摄入高胆固醇饲料的大鼠,具有明显的降胆固醇作用,加入5.0％喂饲四周即出现显著效果,12周时降至正常组水平。肝组织学检查表明具有明显的抗脂肝作用,对Ca、Fe、Zn、Cu的吸收利用未见不良影响。更多还原

【Abstract】 This paper reports a study regarding the verity of the hypocholestero-lemic effect of konjac-polysaccharide. The konnyaku powder (KP) used in this study was prepared and refined from the tubers of Amorphophallus ko-njac K. Koch and contained 84.8% of glucomannan. Male and female Spra-ue-Dawley rats aged 5 weeks were divided into 5 groups and fed on normal basal diet, hypercholesterolemic diet (control diet) and 3 test diets (i.e. KP was added to the control diet at a dosage of 2.5%, 5% or 10%) respe- ctively, for 12 weeks.The results obtained from this study showed that KP could markedly lower the level of the cholesterol in sera and livers of rats feeding hyper-cholesterolemic diets. At the end of the 4th week of the feeding experiment, the serum cholesterol level of the 5% and the 10% KP groups, and the liver cholesterol level of the 10% KP group were shown to be significantly lower than those of the control group. At the end of the 12th week, serum cholesterol levels of all the 3 KP groups were found to be lowered to the level of the normal group and so did the liver cholesterol level of the 10% KP group. The lipotropic (anticholesteatosis) effect of KP was also confirmed by the hepatic histopathological examination. Besides the hypocholest-eroletmic eftect, KP diets can also increase the bulk of stool. Finally, there were not any harmful effects on the absorption and utilization of Ca, Fe, Zn and Cu being found.更多还原