【摘要】 本文采用离体犬基底动脉实验。结果表明脱水长春胺乙酯能对抗5-HT和高钾所致基底动脉收缩,其对5-HT具二重拮抗作用,用Brink作图法求出pA₂为6.06,pD′₂为4.96。更多还原

【Abstract】 Experiment on isolated basilar arteries of dogs showed that ethyl apovincamine-22-oate （Cavinton, CAV）, a new cerebral vasodilator, at 10^-6 mol/L could antagonize the contractile effect of high K⁺（40 mmol/L） on the vessels. At lower concentration (10^-6mol/L), CAV was shown to competitively shift the concentration-response curve of 5-HT(0.5～512×10^-8mol/L) to the right, and at higher concentration (10^-5mol/L), the curve was further depressed. This inhibitory effect of CAV to 5-HT and high K⁺ on cerebral vessels may be beneficial in the treatment of ischaemic cerebral vascular diseases. CAV(5 × 10^-6mol/L)caused a transient contraction of the vessels at resting state. This effect was antagonized by promethazine (10^-5mol/L) and pizotifenum (10^-5mol/L).更多还原