【摘要】 以每周定时im马桑内酯0.9～1.5mg/kg三个月为实验性癫痫慢性发作模型。ig芹菜甲素700mg/kg能明显降低大鼠癲痫发作的程度和次数,延长潜伏期。脑形态学结果表明,芹菜甲素对大脑顶叶皮层细胞、胶质细胞和小脑蚓部蒲肯野细胞有一定的保护作用。同时观察的安定1.5～5mg/kg则无此作用。更多还原

【Abstract】 3-Butyl phthalide was found to have anticonvulsant activity in animal experiments. In the present study, a model of chronic epilepsy was induced by im coriaria lactone 0.9～1.5 mg/kg in rats for 3 months. Ag-1 700 mg/kg ig was shown to prolong the latent period of the epileptic seizures, reduce the severity of the seizures and the number of animals with seizures. Of particalar importance is the fact that, no evidence of lesions in the cerebral neurons, glial cells and cerebellar Purkinje’s cells of the Ag-1 treated animals was observed in histological studies. This result is especially encouraging as Ag-1 may have a protective effect on rat brain cells.更多还原