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红茴香毒性成分和6-Deoxypseudoanisatin的结构研究

THE TOXIC PRINCIPLE OF ILLICIUM HENRYI DIELS AND STRUCTURE OF 6-DEOXYPSEUDOANISATIN

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【作者】 刘嘉森; 周倩如;

【Author】 JS Liu and QR Zhou (Shanghai Institute of Materia Medica, Academia Sinica, Shanghai)

【机构】 中国科学院上海药物研究所; 中国科学院上海药物研究所;

【摘要】 <正> 八角科植物红茴香(Illicium henryi Diels)广泛分布于我国华中和华南各地,其果实常被当作八角误食引起中毒。为了研究其毒性成分和开发利用该植物资源,我们对贵州产的红茴香果实进行了化学研究。从中分得3个倍半萜内酯化合物。其一为毒性成分,小鼠腹腔注射

【Abstract】 This paper reports that three sesquiterpenlactone compounds were isolated from the toxic fruits of Illicium henryi Diels gathered in Guizhou province of China. Two of them were identified as anisatin(Ⅰ) and pseudoanisatin (Ⅱ). The former exhibits high toxicity in mice, meaning that is the toxic principle of the title plant. The third is a new compound, the structure of which was elucidated as 6-deoxypseudoanisatin(Ⅲ) based on spectral evidences. The detailed physical and chemical data are presented in the paper.

  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,1988年03期
  • 【被引频次】16
  • 【下载频次】205
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