【摘要】 辽吉冰凉花总甙（APAW）1.0mg/kg iv,能使麻醉家兔正常心脏的P-dP/dt环体面积（LO）,LV-dP/dt_max,Vpm及LVSP比药前增大,HR减慢。APAW和冰凉花（AAR）及毒毛旋花子甙K（SK）一样,能明显改善衰竭兔心的心功能。静脉恒速输入0.5 mg/ml APAW,25min后,心衰家兔的LVSP,LV—dP/dt max,LO均明显回升,LVEDP降低,t-dP/dt max缩短。三种强心甙的最大强心效力无显著性差异。但APAW的治疗宽度和治疗指数均较AAR和SK为大,而AAR和SK间则无显著性差异。更多还原

【Abstract】 Adonis pseudoamurensis W. T. Wang （APAW） is a new glycoside isolated from the plant Adonis L. In the present study, the inotropic and toxic effects of APAW were studied and compared with those of Adonis amurensis Regel et Radde （AAR） and strophanthin K （SK） in normal heart and experimental failing heart in anesthetized rabbits. In rabbits with normal heart, intravenous injection of APAW （1.0 mg/kg） induced an increase of p-dP/dt loop, LV-dP/dt_max, Vpm and LVSP, while the HR was slightly slowed. After intravenous infusion of APAW （0.5 mg/ml） at a constant speed for 30 min, the LV-dP/dtmax, Lo and LVSP of the failing rabbit heart induced by sodium pentobarbital significantly increased, t-dP/dtmax and LVEDP decreased, while the HR did not change. The peak inotropic effect of APAW was similar to those of AAR and SK. The therapeutic index and the safety margin of APAW were larger than those of AAR and SK. while no difference was observed between AAR and SK. These results indicate that APAW is a promising cardiac glycoside.更多还原