【摘要】 <正> 前列腺素(Prostaglandins,简称PGs)是一类具有生物活性的脂类自体活性物质。人和动物的多种器官和组织均可合成。眼的许多组织,如虹膜、睫状体等也可合成多种PGs。早期的研究得知,它是眼部炎症的主要调节物,并参与人和动物的外源性炎症反应和引起眼压升高。因此眼科领域注重研究PG的抑制剂更多还原

【Abstract】 The hypotensive and other ocular effects were studied for 24 hr after topical application of prostaglandin F_2a(PGF_2ain 45 normal human subjects. After baseune intraocular pressure （IOP） measurements, 62.5μg, 125μg or 250μg of PGF_2a dissolved in 50μl of saline was appned to one eye of 15 subjects for each does test—ad. Contralateral Control eyes received 50μl of saline. Topical application of 62.5 ——250μg PGE_2a caused a significant IOP reduction in PG-treated eyes after drug administration. as compared with the pressure of the control eyes.更多还原