【摘要】 <正> 改变苯环取代基(X)及酰胺氮上的取代基(R)研究桂皮酰胺类化合物与抗惊作用的关系已有一些报道,Balsamo 等发现 E 和 Z-更多还原

【Abstract】 Six pairs of geometric isomers of α-chlorocinnamamides were synthesized.Theirconfigurations were assigned on the basis of their UV λ_maxand the 1^H NMR chemical shiftsof protons on the amide and olefinic bond.The tetrasubstitution on the double bond drasti-cally prevents the coplanarity of the benzene ring with the double bond in the Z and in theE form.But the influence is smaller in the Z form than in the E isomer.So the value ofλ_max of Z form is larger than E form.The diamagnetic anisotropy of the aromatic ring couldbe one of the causes of the relatively higher chemical shifts of the β-H and NH.更多还原