【摘要】 <正> 硫杂脯氨酸(Thiazolidine-4-CarboxylicAcid,简称 TCA)能使肿瘤细胞逆向转化为具有正常特点的细胞。它对鳞状细胞癌、乳腺癌、肾癌、卵巢癌、甲状腺癌等均有肯定的疗效。但 TCA 具有一定的毒性。我们合成了 N-更多还原

【Abstract】 Five glycosyl-esters of N-acetyl thiazolidine-4-carboxylic acid were synthesized viathe esterification of the carboxylic acid with the proper glucopyranose or glucofururonolactonein the presence of DCC,CH₂Cl₂ and pyridine.2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl N-acetyl-DL-thiazolidine-4-carboxylate 3b was also obtained by reaction of silver N-acetyl-DL-thiazolidine-4-carboxylate 4b with 2,3,4,6-tetra-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranose5 in CH₃CN.3a,3b,7,9a and 9b have not been reported in literature.更多还原