【摘要】 对40例骨髓增生异常综合征进行了染色体显带分析,结果发现16例(40%)有克隆性核型异常。其中最多见的类型为+3和20q-,后者见于4例,系国内首次报道。对核型异常的意义也作了简要讨论,认为异常克隆的检出有助于该综合征的诊断和预后估计。更多还原

【Abstract】 Chromosome studies with banding technic on the bone marrow cells of 40 cases of MDS(RA 14 cases,RAEB 15 cases,RAEB-T 3 cases,RARS 7 cases,CMML 1 case) were performedsince 1985.Abnormal clones were detected in 16 cases (40%).Trisomy 8 and a deleted 20q-were found,each in four cases.Complex abnormalities comprising monosomy 5 or a deleted5q- were seen in two cases.Monosomy 7,trisomy 9 with 6q~+,a deleted 9q,monosomy 18with an acentric fragment,a 16;17 translocation,a 11;19 translocation were noted each inone case.In the group,9 cases with abnormal karyotype died,3 of them had developed into leuke-mia.On the contrary,among those with normal karyotype only one died of infection and nonehad transformed into leukemia,so far as we have had observed.We believed that detection of an abnormal clone is beneficial to the diagnosis of MDS ina patient with unclassified pancytopenia,no matter whether an abnormal karyotype is presentor not and its kind of nature may contribute to evaluation of the prognosis of MDS.更多还原