【摘要】 对氯乙烯接触水平为213.21mg/m~3的31名工人和32名对照者进行了检查,表明FEP和Hb均值存在明显差异(P均小于0.01)。将实验组分为肝大组和非肝大组进行比较,肝大组的δ-ALA-μ、CP-μ和FEP均值明显高于非肝大组(P均小于0.05)。肝大组CP—μ超过正常值上限的百分率比非肝大组高(P小于0.005)。接触氯乙烯的工人在肝脏肿大的同时往往可检出卟啉水平的升高,调查结果提示:接触氯乙烯工人卟啉和卟啉前体的测定有可能成为发现早期毒作用损伤的健康监护指标。更多还原

【Abstract】 31 workers exposed to vinyl chloride at the averge level of 213.21mg/m~3 and 32 controls were examined. The preliminary study indicated that there was significant difference in the averages of FEP and Hb between test group and control (P<0.01).The test group was divided into 2 group (hepatomegaly and un-hepatomegaly) average levels of δ-Ala-μ. CP-μ and FEP were all increased significantly in the hepatomegaly (P<0.05). Percentages over upper limit of normal value of CP-μ in the hepatomegaly group was higher than un-hepatomegaly group(P<0.005). Elevated porphyrin levels and hepatomegaly were often found in worker, exposed to vinyl chlorides. The results suggested that determination of porphyrins, and porphyrin precursors in workers exposed to vinyl chloride might become a valuable health surveillance index to indicate early signs of toxic injury.更多还原