【摘要】 Wistar成年大鼠72只,用微量注射6-羟多巴胺破坏一侧黑质,1月后经无水吗啡激发旋转试验,有40只大鼠制成“旋转鼠”模型,占55.6%。取30只“旋转鼠”分别植入大鼠胚胎中脑组织块和细胞悬液于黑质损伤侧的尾核头部背侧,胚胎为E₁₂、E₁₅、E₁₈,移植后1月和3月药物激发旋转试验时,发现植入E₁₅中脑组织的大鼠旋转次数减少最明显,与植前相比植后1月P<0.05,植后3月P<0.001。更多还原

【Abstract】 Observations were made on 72 adult white Wistar rats. Unilateral substantia nigra(SN) was destroyed by microinjection of 6-hydr- oxydopamine (6-OHDA), 1 month later Apomorphine was used for induce rotation. 40 became "tarning rats" . Positive rate was 55.6%. "Turning rats" (n=30) received embryonic mesencephalic tissue and cell suspensions transplantation at back of head of caudate nucleus. Embryonic ages were 12, 15 and 18 days (E12, E15, E18). Rotation tests were done 1 and 3 months after transplantation. The E15 is the best one of the three. The differences are very significant(P<0.001) at 3 months after transplantation.更多还原