【摘要】 本文用对人胎盘型谷胱甘肽S-转移酶(GST-π)抗体的ABC法检查了38例胃癌和28例胃癌前期病变及22例正常胃粘膜。观察结果表明,GST-π阳性物质为棕色,分布于细胞浆内,根据其在细胞内分布的特点可分为胞质型、周边型、分泌型和印戒型。胃腺癌组织中GST-π的阳性率可达95％以上,胃粘膜的不典型增生和肠上皮化生组织中阳性率分别达100％和85％,且活性高,但粘液腺癌、印戒细胞癌和未分化癌组织中GST-π阳性率低,而且活性也低。作者认为GST-π可作为人类胃癌和胃癌前期病变的新的标志酶。更多还原

【Abstract】 This article describes dietribntion and phenotype of GST-π in 38 cases of gastric carcinomas and 28 cases of gastric precancerous lesion and 22 cases of normal gastric mucous membrane. The results showed that positive substances for GSTπ staining were brown and were distributed incytop lasma. According to the characterastics of distribution in cytoplasma, it can be divided into cytoplasma type, periphery type, secretory type and ring cell type. The positive rates of GST-π in organ with gastric adenocarcinoma could reach more than 95％, the positive rates of GST-π in mucous of adenocarcinoma, ring cellular carcinoma and undifferentiated cancer wer low andits activitywas weakened. The- refore it is suggested that GST-π could beregarded as a type of new mark enzyme in gastric carcinoma and gastric premalignant states in human.更多还原