【摘要】 本文证实了人巨细胞病毒(HCMV)感染能在人成纤维母细胞上诱导IgGFC区受体(FcR)。血吸附试验表明:IgGFcR的表达以感染后第4天为最高,而且与接种病毒的滴度正相关(r=1,P<O.05),过氧化物酶技术也证实了这一点。人IgG以及HCMV阳性血清对血吸附的抑制表明所诱导的受体为IgG受体。载有蛋白质A的葡萄球菌吸附试验的阳性结果进一步表明所诱导的受体是IgGFcR。过氧化物酶技术对FcR的检测比血吸附试验敏感。更多还原

【Abstract】 This paper presents the demonstration of the IgG-Fc receptor induced in cultured huma fibroblasts by HCMV infection. Hemadsorption test showed that the expression of IgG-Fc receptor was the highest on the 4th day after infection and correlated positively with the titres of virus innoculated. Peroxidase technique also confirmed this. the inhibition of hemadsorption by human IgG or anti-HCMV serum indicated that the induced receptor is for IgG. The adsorption tests with Staphylococcus aureus bearing protein A ( a natural Fc receptor ) showed that the induced receptor is of the IgG -Fc type. It was also found that peroxidase technique is more sensitive in detecting FcR than hemadsorption tests.更多还原