【摘要】 用随机、双盲、交叉对照法,以戊四硝酯片作为对照药,评定盐酸地尔硫(艹卓)治疗冠心病心绞痛180例的疗效。显示用中等剂量、1个月的疗程,症状总有效率为94.9％,静息心电图总有效率为49.7％,心电图运动试验总有效率为52.2％.此外心率减慢、血压降低、心率收缩压二重乘积和左心室收缩时间间期改善,全血粘度和血小板聚集可能降低。而不良反应发生率不高。经配对X~2检验,其效果优于戊四硝酯片。更多还原

【Abstract】 Effect of diltiazem hydrochloride. oh coronary heart disease with angina pectoris was investigated in 180 cases by randomized, double blind and cross-over tests with pentaerythritol tetranitrate as control. In short term therapy,one month as a rule, with small to moderate doses i.e. 90-180 mg/d or at most 270 mg/d, the clinical effective rate was found to be 94.9% while the improvements of myocardial ischemic changes in resting EGG was 49.7% and in exercised ECG 52.2%. At the mean time patient’s heart rate reduced, blood pressure lowered, the product of heart rate and blood pressure returned within the safety range, and the left ventricular systolic time intervals improved. The blood viscosity. and platelets aggregation seemed also to be decreased.Side effects were minimal. In general, the effect of diltiazem is definitely更多还原