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亚硒酸钠对艾氏腹水癌(实体型)生长的抑制作用

Antitumor Effect of Sodium Selenite on Ehrlich Ascites Tumor (Solid Form)

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【作者】 倪璇; 王继尧;

【Author】 Ni Xuan, Wang JiyaoDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical University, Wuhan

【机构】 同济医科大学公共卫生学院营养与食品卫生学教研室; 同济医科大学公共卫生学院营养与食品卫生学教研室;

【摘要】 本文用“肿瘤抑制率”为指标,观察亚硒酸钠对艾氏腹水癌(实体型)生长的抑制作用。3个实验组小鼠腹腔注射亚硒酸钠,剂量分别为1/7LD50(3.50mg/kg体重)、1/10LD50(2.45mg/kg体重)和1/30LD50(0.82mg/kg体重)每日给药1次,共7天。结果以1/10LD50组的“肿瘤抑制率”为最高,经体重校正瘤重后,“肿瘤抑制率”仍高达35.59%。

【Abstract】 Inhibition ratio was used as an index to observe the antitumor effect of sodium selcnite on Ehrlich ascites tumor (solid form). Sodium selenite was given I.P. to all 3 experimental groups of mice; the dose was 1/7 LD50(3.50mg/kg body wt.), 1/10 LD50 (2.45mg/kg body wt) and 1/30 LD50 (0.82mg/kg body wt) respectively, given once a day for 7 days. The results showed that 1/10 LD50 group had the highest inhibition ratio, amounting to 35.59% even after checking the tumor weight by body weight.

  • 【文献出处】 同济医科大学学报 ,Journal of Tongji Medical University , 编辑部邮箱 ,1988年05期
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