【摘要】 冬眠蟾蜍的肝脏对不同浓度酒精反应敏感性不同,组织化学观察表明,随着酒精浓度的增加、喂酒时间延长,糖原(PAS反应)、ATPase、G-6-Pase、SDH的活性和反应由减弱至消失;ACP、AKP活性则不断增高。动物在试验初期,早春初醒,活跃自如,不久即反应迟钝,死亡率随酒精浓度的增高、喂酒时间的延长而增高。冬眠蟾蜍的“生物时钟”可因外界因素的刺激而受干扰。更多还原

【Abstract】 60 Hibernatting Bufo bufo (40-62g) were divided into four groups (A, B, C, D). group A was treated, with 40% glucose 1 ml p .o. Bid, and in other three groups, 10%, 25%, 50% alcohol mixed with 40% glucose were administrated P, O, respectively, The results showed that the reaction or activity of PAS ATPase, G-6-Pase and SDH were inhibited, and the activity of ACP and AKP were elevated in groups B, C, D, while under the microspectroscope the quantitated activity of SDH and G-6-Pase in group A was much higher than in other groups.The results indicated that the decrease of histochemical reaction in groups B, C, D was directly proportional to concentration of alcohol given and the duration of treatment. Our study suggested long term administration of larger dose of alcohol, may induce damage to liver in groups B, C, D.更多还原