【摘要】 本实验提示在大鼠口服乙二醇形成结石的过程中,草酸钙晶体主要出现在肾小管腔内,与小管上皮关系密切,并有明显的极性。晶体的存在可以影响肾小管的结构改变,随着近曲小管微绒毛刷状缘的丧失及上皮细胞的坏死,晶体便脱落至管腔。晶体表面因复盖有细胞碎片和基质而容易引起聚集,聚集的晶体与暴露的基底膜接触,对微结石的形成起核心作用。本文还对草酸钙晶体两种基本结构的形态及其与草酸钙晶体形成的关系,进行了阐述和讨论。更多还原

【Abstract】 The formation of calcium oxalate crystals was induced in rat kidneys by administration of ethylene glycol. Calcium oxalate, crystals were found mainly in the lumina of renal and closely associated with the tubular epithelium,and the crystals exhibited a distinct polarity. Existence of crystals can influence alterations in the structure of renal tubules. With loss of microvillous brush border and necrosis of epithelial cells, the crystals are sloughed into the tubular and become coated with cellular debris, which facilitate their early aggregation. Some crystalline aggregates coming in contact with an exposed basement membrane become attached and play an important role in the formation of microliths. Morphology of the two basic types of calcium oxalate crystals and their relation to oxalate crystal formation have also been discussed in this paper.更多还原