【摘要】 作者研究了慢性间断低压缺氧对大鼠肺血管反应性的影响及其与组胺的关系。动物经慢性缺氧后发生慢性肺动脉高压,其肺血管对急性缺氧的反应性降低。联合使用扑尔敏和甲氰咪胍阻断组胺受体后,对照大鼠肺血管反应性明显增强,慢性肺动脉高压大鼠肺血管反应性无明显改变。结果表明组胺可能参与大鼠肺血管反应的调节,慢性肺动脉高压大鼠由于对急性缺氧的肺血管收缩反应较弱,因而组胺的调节作用也较弱。更多还原

【Abstract】 The effect, of chronic intermittent hypobaric hypoxia on pulmonary vascular reactivity to acute hypoxia in. rats and its relationship to histamine have been studied. Exposing to chronic intermittent hypoxia for 3 weeks resulted in chronic pulmonary hypertension and decrease in hypoxic pulmonary vasconstriction (HPV), The administration of chlorpheniramine and cimetidine increased significantly the HPV in rats with normal Ppa, while not changed in rats with chronic pulmonary hypertension. It is suggested that histamine may play a role in modulating HPV in rats, and this effect seems to be depressed in rats with chronic pulmonary hypertension as their HPV reduced.更多还原