【摘要】 将本室制备的免疫导向药物-抗人脑胶质瘤单克隆抗体SZ-39和阿霉素交联物在脑胶质瘤裸小鼠模型NHG-1体内进行导向治疗研究。实验显示免疫交联物对胶质瘤的抑制作用显著优于游离药物、游离抗体及药物和抗体的混合物。免疫交联物治疗后肿瘤组织~3H-TdR掺入量显著低于各对照组,表明肿瘤细胞DNA合成被明显抑制。而免疫交联物对正常小肠上皮细胞DNA合成影响较小,提示其副作用较小。更多还原

【Abstract】 Anti-human glioma monoclonal antibody SZ-39-adriamycin immunoconjugates were applied for targeting chemotherapy of brain glioma in the nude mouse model. Immunoconjugates produced more significant antitumour effects in vivo as compared with those of free drug, free antibody and drug mixed with antibody groups. The uptake of ~3H-TdR of the tumour tissue after immunoconjugate treatment was least in all treatments, and implies that DNA synthesis of the tumour cells was inhibited. The incorporation of ~3H-TdR of the small intestine was not affected by immunoconjugate chemotherapy, and indicates that the detrimental effect of immunoconjugates on the normal cells was slight.更多还原