【摘要】 本文研究了615近交系小鼠的自发性可移植性肺癌(P₆₁₅)和肝癌(H₆₁₅)组织中神经节苷脂结合唾液酸含量和神经节苷脂图谱。P₆₁₅和H₆₁₅癌组织中GLS结合唾液酸含量均比正常对照为高,分别为对照组织的2.9倍和1.9倍。615小鼠的正常肺组织和肝组织的GLS主要成分均为GM₃。在P₆₁₅和H₆₁₅癌组织中GM₃含量均明显减少。肺癌组织中GM₂大量增加,肝癌组织中不仅GM₂明显增加,GM₁和GD₁₈也明显增加。P₆₁₅和H₆₁₅这两种分化程度较高、恶性程度较低的癌组织GD₃的百分含量比正常对照组织略有降低。本文结果提示,自发性可移植性P₆₁₅和H₆₁₅肿瘤组织中不仅神经节苷脂含量（以唾液酸量计）升高,而且GLS的组分也发生改变。GM₃含量减少和GM₂含量增高可能与肿瘤的恶性生长和分化程度有关。更多还原

【Abstract】 High performance thin-layer chromatoqrams and the contents of gangliosides (GLS) in spontaneous transplantable lung cancer (P615)and hepatoma(H615)in 615-strain inbred mice have been studied. Contents of GLS bound sialic acid in carcinoma tissues in P615 and H615 increased to 2.9 and 1.9 times of normal controls, respectively.The major GLS in control tissues of normal lung and liver was GM3 which has decreased in the tumor tissues of P615 and H615. However, GM2 has increased in lung cancer and hepatoma tissues, GM1 and GD1a have increased only in hepatoma.P615 and H615 belong to carcinomas having higher differentiation and lower malignity,in which the contents of GD3 were less than those in control. The results suggested that not only the total amount but also the % composition of GLS in spontaneous transplantable tumors may be altered. It also suggested that GM3 decrease and GM2 increase may be related to the malignant growth and the differentiation of the cancers.更多还原