【摘要】 为了对我室研制的幼儿用气动隔膜泵今后的临床应用提供依据,进行了离体和在体两方面的评价。模拟实验表明,影响泵输出量的主要因素是驱动正压和频率,而驱动负压作用相对较小。在驱动正压150～220mmHg间,泵输出量随正压加大而提高;在一定的驱动频率范围内和驱动正压下,泵输出量随频率增加而提高;仅就驱动负压而言,在-40～-60mmHg间.泵输出量最大且无明显变化,因此较为合适的驱动负压是-40mmHg。动物实验结果显示,当心衰犬的主动脉平均压在65mmHg以下时,驱动正压仅150mmHg、负压-40mmHg、频率75bpm条件下,即可达到90％的辅助流率,这就提示在今后的临床应用中,无需采取过高的驱动正压。动物实验证明泵最大每搏量为15.5ml,达到了每搏量15ml的设计要求,如驱动频率在60bpm以上,可达900ml左右的辅助流量,因而能满足15公斤以下体重幼儿患者心脏辅助的需要。更多还原

【Abstract】 The pneumatically driven diaphragm pump for pediatric use made in our research unit is evaluated in vitro and in vivo.In vitro experiments, the output of the pump increased with the increasing air pressure ranging 150-200mmHg. Under certain pumping rate and driving pressure, the output of the pump increased with the increasing pumping rate. As for the vacuum pressure, when the vacuum pressure was in the range of-40～-60mmHg, the output of the pump reached the maximum. So -40mmHg was regarded as the suitable vacuum pressure. Factors that influence the output of the pump were the driving pressure and the pumping rate.In vivo experiments, when the mean aortic pressure of the canine developing heart failure was under 65mmHg, with only 150mmHg driving pressure(-40mmHg vacuum pressure, 75bpm pumping rate), the LHB (Left Heart Bypass) flow ratio was up to 90％. The stroke volume of the pump in animal experiments was 15.5 ml which agrees to the designing parameter. If the pumping rate was above 60 bpm, the output of the pump could reach 900 ml/min, which can satisfy the pediatric candidates weighting under 15 kilograms.更多还原