【摘要】 从不同地理区域来源的甲型肝炎病毒于不同培养温度条件下,在人二倍体细胞中连续传代进行减毒,再经狨猴试验了解其免疫原性和安全性。研究结果表明已获得数株以狨猴为实验基础的合适甲型肝炎减毒株。攻击试验表明在狨猴体内可产生牢固的免疫力。这些甲型肝炎减毒株可供进一步人体试验研究。更多还原

【Abstract】 Hepatitis A virus (HAV) from different geographical regions was attenuated by ser rial passages in human diploid fibroblast cell cultures. A number of virus preparations with different levels of virulence for marmosets was obtained, of which several could be used to develop a live, attenuated hepatitis A vaccine for human use.更多还原