【摘要】 本文研究8例烧伤总面积60.3±19.7％男性成年病人,用¹⁵N-甘氨酸示踪技术测定总体蛋白质代谢速度,用尿3-甲基组氨酸排出量估计肌肉蛋白质分解速度。结果示烧伤病人总体蛋白质的流量（Q）、合成（S）和分解速度（C）分别为9.20±1.54、6.10±0.77、7.07±0.97g/kg/d,相当于3名正常对照的2.0、1.9和2.3倍。烧伤病人尿3-甲基组氨酸排出量为8.40±2.22μmol/kg/d,相当于分解肌肉蛋白质2.00±0.54g/kg/d,此数值是4名正常对照的2.8倍。统计学分析表明总体蛋白质代谢的Q、S、C都与蛋白质摄入量（Ⅰ）有显著的正相关性;总体蛋白质分解与肌肉蛋白质分解之间也有显著的正相关性。更多还原

【Abstract】 Eight male adults with burn area 60±20％ BSA were studied. ¹⁵N-glycine tracing technique was used to determine total body protein kinetics, and urinary 3-methylhistidine （3MH） excretion was measured to evaluate muscle protein catabolism. The results showed that the total body protein metabolic flux （Q）, synthesis （S） and catabolism （C） in these patients were 9.20±1.54, 6.10±0.77, 7.07±0.97g/kg/d respectively, which were 2.0-, 1.9-, 2.3-fold those of 3 normal subjects. The urinary 3MH excretion in the burn patients was 8.40±2.22 mol/kg/d which was 2.8-fold that of 4 normal subjects. Statistic analyses showed that there were significant correlations between protein intake （Ⅰ） and Q, I and S, I and C, and C and muscle protein catabolism, but no correlation was found between I and net protein synthesis.The authors deem that the dramatic elevation of body protein metabolic rates indicates a peripheral to visceral protein transloation, The high protein intake thus provides both exogenous protein and endogenous amino acids through promoting protein translocation.更多还原