【摘要】 本工作建立了测定片剂中氨酰心安的荧光分光光度法。片粉经甲醇提取并稀释后即可测定荧光值(λ_ex278nm,λ_em301nm)。本品在甲醇溶液中荧光值稳定,各种辅料无干扰,方法线性良好（r=0.9999）,精密度高,同次测定平均回收率100.16±1.27％;不同次测定平均回收率100.04±1.30％。按本法测定三种片剂共7个批号百分含量为98.09～100.04％。更多还原

【Abstract】 A simple and rapid spectrofluorometrio method for the assay of atenolol in tablets is described. No previous separation was required. Methanol was used to dissolve atenolol in powdered tablets and after dilution the fluorescence of the derived solu-ion was measured (λex 278 nm, λem 301 nm). The concentration was calculated according to calibration graphs. Other components of the tablets, such as chlorthali-done and excipients, did not interfere. Experimental results exhibited a good coefficient of correlation (r = 0.9999), precision (CV, 0.28-1.84%) and average recoveries (intra-assay, 100.16 ± 1.27 %; inter-assay, 100.04±1.30%). Seven batches of three different tablet forms were assayed and the atenolol contents were found to be 98.09-100.04 %.更多还原