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定量立体学在非何杰金淋巴瘤分类中的意义
THE SIGNIFICANCE OF QUANTITATIVE STEREOLOGY IN THE CLASSIFICATION OF NON-HQDGKIN’S LYMPOHMAS
【摘要】 用图像分析仪进行立体学定量测量,统计52例非何杰金淋巴瘤细胞的平均核体积,结果显示小淋巴细胞、小核裂细胞、大核裂细胞、小无核裂细胞、大无核裂细胞和免疫母细胞性淋巴瘤的平均核体积,分别为81.47±10.04μm~3,125.50±23.50μm~3,238.88±35.63μm~3,329.20±77.60μm~3,654.11±52.25μm~3和1177.75±160.37μm~3,作者按立体学原理,以测量肿瘤细胞的平均核体积的方法作分类是一种新的尝试,具有客观和重复性好的优点,而且易于为初学者所掌握,在病理诊断中有一定实用价值。
【Abstract】 Non-Hodgkin’s lymphomas are a group of heterogenous neoplasms, which have been variedly classified, resulting in confusion and controversy. The aim of this study is to provide a new classification of these lymphomas according to their morphometric data and stereologic nuclear volume. The volume of more than 100 tumor cells for each of 52 cases of lymphoma specimen were measured by using image analyser (VIDS III). The mean nuclear volume of the small lymphocyte, small cleaved lymphocyte, large cleaved lymphocyte, small non-cleaved lymphocyte, large non-cleaved lymphocyte and immunoblastic lymphocyte were 81.47±10.04μm3, 125.50±23.50 μm3, 238.88±35.63μm3, 329.20±77.60 μm3, 654.11 ± 52.25μm3 and 1177.75±160.37 μm3 respectively. It is considered that classification according to stereologic data of the mean nuclear volume is more objective and reproduceable and more readily mastered.
【Key words】 malignant lymphoma; non-Hodgkin’s lymphoma; stereology; image analyzer; classification; nuclear mean volume;
- 【文献出处】 上海医科大学学报 , 编辑部邮箱 ,1988年06期
- 【被引频次】3
- 【下载频次】11