【摘要】 120对1:2配对病例对照研究结果表明,1988年上海地区甲型肝炎暴发流行与接触肝炎患者、外出用餐、注射或输血、服用某些药物等传播途径无关,而与生食毛蚶有关（OR=23.20,X²=69.22,p<0.0001）,且罹患甲型肝炎的危险性OR值随生食毛蚶量上升（X_t²=62.11,p<0.0001）,控制年龄混杂因素后,仍有剂量反应关系。病例家属和（或）对照家属生食毛蚶者比未生食毛蚶者罹患甲型肝炎的危险性要高(OR=9.01,X^MH2=29.97,p<0.0001)。更多还原

【Abstract】 A case-control study of 120 matched pairg (1:2) was carried out to study the transmission of an outbreak of hepatitis A in Shanghai, 1988. The results revealed that the transmission was mainly due to eating raw clams, Arca (Anadara) suberenata (OR = 23.20, x2 = 69.22, p<0.0001), but was not related to the other factors sach as contacting with hepatitis patients, eating out, injection or transfusion and taking medicine. Odds ratios of hepatitis A were increasing with the amounts of raw clams taken and Chi-square trend test was very significant (xt2 = 62.11, p<0,0001).Dose-response relationship still existed when the age factor was excluded.Case and/or control households taking raw clams had greater risk to acquire hepatitis A than those without (OR = 9.01, xMH2 = 29.97, p<0.0001).更多还原