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中药灯盏花的生药鉴定及其与两种近缘植物对离体猪冠状动脉的作用

A PHARMACOGNOSTICAL IDENTIFICATION OF THE CHINESE DRUG“DENG ZHAN HUA”AND THE EFFECT OF THE DRUG AND TWO RELATIVE SPECIES ON ISOLATED PIG CORONARY ARTERIES

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【作者】 郭济贤; 竺叶青; 李颖; 杨瑞萍; 潘伟坚; 张云扬; 江文德;

【Author】 Guo Jixian, Zhu Yeqing, Li Ying, Yang Ruiping, Pan Weijian Zhang Yunyang, Jiang Wendee(Department of Pharmacognosy, School of Pharmacy, and Department of Pharmacology, Faculty of Basic Medical Sciences, Shanghai Medical University, Shanghai)

【机构】 上海医科大学药学院生药学教研室; 上海医科大学药学院; 上海医科大学药学院基础医学部药理学教研室; 上海医科大学药学院基础医学部药理学教研室 药学专业1981级毕业生; 药学专业1981级毕业生;

【摘要】 本文对灯盏花(云南产)进行了生药鉴定研究,包括生药性状及叶与花的表面显微特征等。为了扩大药源,观察了灯盏花及其两种近缘植物一年蓬和小飞蓬(上海野生)总黄酮的水溶性部位对离体猪冠状动脉的影响,结果三者均能程度不同地舒张离体猪冠状动脉的收缩状态,提示后两种植物值得进一步研究与利用。

【Abstract】 The Chinese drug"DENG ZHAN HUA"(Herba Erigerontis) specified in the Chinese Pharmacopoeia 1977 edition is the dried herb of Erigeron breviscapus (Vant.) Hand.-Mazz. (EB), family Compositae. The herb and its preparation have been reported to be effective in treating paralysis.In this paper, the morphological and histological characters of the leaves and flowers of the crude drug are described with illustrations.Results of pharmacological investigations show that the water-soluble fractions of the flavonoids extracted from the dried herbs of EB, and two relative species, E. annuus (L.) Pers. (EA) and Conyza canadensis (L.) Oronq. (E. canadensis L.) (CO) could dilate the isolated pig coronary arteries very signifioantly. Therefore, EA and CO are worthy of further study and utilization.

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