【摘要】 静脉注射大肠杆菌内毒素造成家兔内毒素休克模型。电镜观察其主要脏器超微结构的结果:心肌细胞的肌膜向外发出许多细长绒毛样突起,肌丝排列紊乱、断裂,并可出现肌纤维溶解消失等变化。毛细血管内皮形成许多边缘突伸向腔内。神经细胞的粗面内质网常有脱颗粒、囊扩张现象。在心肌与神经细胞内均可见到线粒体肿胀、嵴排列紊乱、结构破坏,及形状、大小差异较大的现象。肾近曲小管细胞的胞质内有大量溶酶体。更多还原

【Abstract】 Electron microscopic observations on the ultrastructures of the heart, brain and kidney were made in endotoxic shock model rabbits employing E. coli toxin injected intravenously. The sarcolemma of the cardiac muscle extended outwards forming numerous slender villous projections. Disarrangement and fragmentation of the myofilaments, and even disruption and dissolution of the myofibers were found. Many marginal folds formed from the surfaces of endothelial cells extending into the lumen. Degranulation and distention of the cisternae of rough endoplasmic reticulum are common in neurons, swelling mitochondria, with disordered and disrupted cristae, or mitochondria of irregular sizes and forms could always be seen in both cardiac muscles and neurons. A lot of lysosomes were seen in the cytoplasm of the renal proximal convoluted tubule cells.更多还原