【摘要】 应用国产磷酸咯萘啶治疗非洲桑给巴尔籍140例恶性反复发作性疟疾,应用4mg/kg 体重深部肌肉注射,6小时后复注一次。若48小时后疟原虫不转阴者再给药一次。观察退热时间及疟原虫转阴时间均显著短于30例应用氯喹治疗的对照组(P<0.001)。且对氯喹耐药虫株同样有效。治疗期间作用药前后ECG,肝功能及尿常规检查说明本品杀虫作用强、副作用少。更多还原

【Abstract】 Pyronaridine is a new erythrocytic schzontocide with no evidence of cress resistance with chloroquine.T-rials on its efficacy were carried out in Zanzibar, Africa, from May,1986 to May,1987.140 falciparum mala-rial cases aged from 6 months to 65 years(including 117 children and adults;10 cases of cerebral malaria 4 pre-gnant women,8 chloroquine resistant cases)were treated by intramuscular route(4mg/kg,twice daily by a day)All the cases were cured rapidy and tolerated the drug.Meanwhile 30 cases were treated with routine chlor-quine therapy as a control.The mean fever time was 22.1±4.3h and the mean parasite time was 39.8±4.8h inthe former cases,which were considerably less than 66±7.9h and 180±23.7h(P<0.01)in the latter respec-tively.All the cases underwent ECG and routine urinalysis.In 70 cases liver function test was done,but nomarked abnormality was shown.更多还原