【摘要】 应用单克隆抗体及绵羊红细胞E玫瑰花环形成实验对22例骨髓增生异常综合征（MDS）病人的外周血T细胞总数及亚群变化进行了测定,结果表明MDS病人总T细胞减低,辅助T细胞亦减低,OKT₄/OKT₈比例失调,提示MDS发病病因中存在由T细胞数量之间平衡失调而导致的造血异常。同时,我们测定了病人的免疫球蛋白定量,结果表明MDS病人组IgG和IgA均较正常人组低,可能与T细胞亚群变化有关。本文将对22例MDS病人用表面受体和单克隆抗体来确定的T淋巴细胞亚群及所测得的免疫球蛋白的结果分析讨论。更多还原

【Abstract】 In this paper, 22 patients with Myelodysplastic syndrome (MDS) were stuied used OKT3, OKT4 and OKT8 monoclonal antibodies together with SRBC rosetts. The results were shown that there was a consistent and significant reduction of T lymphocytes in peripheral blood. This reduction was partialy confined to the OKT4-helper subpopulation. OKT4/OKT8 ratio was reverse. The results suggested that in the pathegenesis of MDS, there be a imbalance of T cell population. Meanwhile, we determined that IgG and IgA of 22 patients with MDS are lower in MDS than in nomal. It is possible that the change should be caused by abnomal T cell subsets.更多还原