【摘要】 以500mg/kg,100mg/kg,50mg/kg,10mg/kg,0mg/kg醋酸铅在第6天～12天给孕小白鼠灌胃(容积1％),结果见500mg/kg,100mg/kg,10mg/kg剂量组胚胎吸收率增高,500mg/kg组达100％。100mg/kg,50mg/kg剂量,可导致胎鼠体重降低,胸骨骨化完整率降低,在100mg/kg组胎鼠近端趾骨、尾椎的骨化程度低于对照组。另外,实验见有胎鼠肝大现象。本次实验未见胎鼠畸形。作者认为,醋酸铅经口给予小白鼠可产生较大的胚胎毒性,影响胎鼠的体重、内脏、骨骼发育,提出了致畸作用与铅的进入途径及给予量有关等一系列问题。更多还原

【Abstract】 Pregnant mice were given daily doses of 500, 100, 53, 10,0mg/kg lead acetate body weigh orally in pregnancy of 6～12 days. The embryo absorptivities in groups of 500, 100, 10mg/kg were higher than control, it was up to 100% in the first group, 100, 50mg/kg produced lower fetus weigh, and degree of sternebrae ossification agenesis, and lower number of ossification centers in promix phalanx and caudal in group of 100mg/kg. Moreover we observed fetus liver enlargement. There was no malformation in the fetus. From the result, it was considered that lead acetate lead to high embryotoxity and interfered the growth of weigh, viscera and skeleton of fetus. The relation between teratogenicity and entered route and dose of lead was gput forward.更多还原