【摘要】 古洛糖酸伯喹（Primaguine Gulonate,PQG）iv 1—2mg/kg可使家兔异丙肾上腺素（IPA）加快心率的量一效曲线明显右移,并抑制最大效应。这种非竞争性对抗IPA加快心率的作用不可被阿托品对抗。PQG明显降低离体大鼠右心房肌的收缩幅度和窦性频率、明显降低离体兔左心房由肾上腺素诱发的异位节律点的自律性,提示古洛糖酸伯喹抗心律失常机制与其直接抑制心脏有关,也可能与共影响N⁺、K⁺和Ca⁺⁺转运有关。更多还原

【Abstract】 1—2mg/kg of Ⅳ primaquine gulonate（PQG） could make isopr（?）nal- ine（IPA） in rats increase heart rate the dose-effect curvc could be shifted remarkably to the right and the maximal efficacy of IPA inhibited.PQG antagonized IPA accelerating heart rate non-competitively. The non-competitive effect was not influenced by atropine.PQG markedly decreased the amplitude of contraction and the sinus rate in the isolated right atria of rats. PQG also markedly decresed automaticity of the ectopic focus induced by adrenaline in the isolated left atria of rabbits.These results suggest that the machanism of the anti-arrhythmic effect of PQG seems to inhibite cardiomuscular directely.It is also possible that PQG is associated with transportation of Na⁺,K⁺ and Ca²⁺.更多还原