【摘要】 应用放射免疫分析法对463例各型病毒性肝炎及450例正常人空腹血清结合胆酸(CCA)进行测定,并与常规肝功能试验进行比较,提示CCA在急性黄疸型,亚急性重型及慢性活动性肝炎起病时显著升高,且为肝功能的一种敏感检测方法,有一定的临床价值。更多还原

【Abstract】 The fasting serum conjugated cholic acid in 450 normal subjects and 463 patients with virus hepatitis was determined by RIA method. The mean value was 0.32±0.28mmol/L in normal subjects. There was no significant difference by sex and age. The value in patients was significantly higher than that in normal subjects (P<0.01). Compared with other conventional liver function tests. The highest value was found in patients with acute icteric hepatitis, subacute severe hepatitis and chronic active hepatitis. The percentage of abnormality of CCA in virus hepatitis was much higher (P<0.01) than that of GPT, TTT, biliubin and A/G. In patients with chronic active hepatitis. Subacute severe hepatitis and Gholestatic hepatitis, the percentage of CCA is higher (P<0.05) than that of GPT. It is suggested that serum conjugated Cholic acid estimation is avery sensitive test of the liver function. In patients with chronic hepatitis the CCA level is more sensitive than conventicenal Iiver function test as an indicator of Iiver damage.更多还原