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THERMODYNAMIC PROPERTIES-ANTICONVULSANT ACTIVITY RELATIONSHIP IN SOME β-SUBSTITUTED CINNAMAMIDES

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【作者】 刘云娜雷小平王书玉刘维勤

【Author】 LIU YUNNA (Institute of Chemistry, Academia Sinica, Beijing) LEI XIAOPING WANG SHUYU LIU WEIQIN (School of Pharmaceutical Sciences, Beijing Medical University)

【机构】 Institute of ChemistryAcademia SinicaBeijingSchool of Pharmaceutical SciencesBeijing Medical UniversityBeijing Medical University

【摘要】 <正> Melting point (T_m), melting enthalpy (△H_m), melting entropy (△S_m) are important thermodynamic parameters of compounds. The thermodynamic parameters of a series of β-substituted para-chlorocinnamamides were first reported in this note. Cinnamamides display a variety of pharmacological actions. The relationship between their structure and anticonvulsant activity in particular has been studied extensively. Literature reported that the partition coefficient (log p, octanol/water), dipole moment and inductive effect index (Ⅰ) of the compounds, Hammett

  • 【文献出处】 Science Bulletin ,科学通报(英文版) , 编辑部邮箱 ,1988年19期
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