THERMODYNAMIC PROPERTIES-ANTICONVULSANT ACTIVITY RELATIONSHIP IN SOME β-SUBSTITUTED CINNAMAMIDES

【摘要】 <正> Melting point (T_m), melting enthalpy (△H_m), melting entropy (△S_m) are important thermodynamic parameters of compounds. The thermodynamic parameters of a series of β-substituted para-chlorocinnamamides were first reported in this note. Cinnamamides display a variety of pharmacological actions. The relationship between their structure and anticonvulsant activity in particular has been studied extensively. Literature reported that the partition coefficient (log p, octanol/water), dipole moment and inductive effect index (Ⅰ) of the compounds, Hammett更多还原