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THERMODYNAMIC PROPERTIES-ANTICONVULSANT ACTIVITY RELATIONSHIP IN SOME β-SUBSTITUTED CINNAMAMIDES
【摘要】 <正> Melting point (T_m), melting enthalpy (△H_m), melting entropy (△S_m) are important thermodynamic parameters of compounds. The thermodynamic parameters of a series of β-substituted para-chlorocinnamamides were first reported in this note. Cinnamamides display a variety of pharmacological actions. The relationship between their structure and anticonvulsant activity in particular has been studied extensively. Literature reported that the partition coefficient (log p, octanol/water), dipole moment and inductive effect index (Ⅰ) of the compounds, Hammett
【关键词】 cinnamamides;
anticonvulsant activity;
thermodynamic parameters;
DSC;
【Key words】 cinnamamides; anticonvulsant activity; thermodynamic parameters; DSC;
【Key words】 cinnamamides; anticonvulsant activity; thermodynamic parameters; DSC;
- 【文献出处】 Science Bulletin ,科学通报(英文版) , 编辑部邮箱 ,1988年19期
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