【摘要】 本文在不同的甲状腺机能状态下,定量研究了大鼠胃溃疡愈合率的变化。大鼠摄取硫氧嘧啶(0.1％水溶液作饮水,饲养10天),引起实验性甲状腺机能低下(甲低组)。给予大鼠0.1％硫氧嘧啶的同时,给予甲状腺素(3μg/100g体重/日)10天,引起实验性甲状腺机能轻度亢进(甲轻亢组)。大鼠用过量甲状腺素(10μg/100g体重/日)10天,引起实验性甲状腺机能亢进(甲亢组)。对照组为正常大鼠,不作任何处理。然后用少量冰醋酸注射入胃粘膜下层造成胃溃疡。各组动物继续给药10天后,测量胃溃疡面积和容积,并计算愈合率。实验结果表明:甲低组溃疡容积(7.71±0.52mm~3;对照组:5.5±0.78mm~3)和面积(8.29±0.90mm~2;对照组:4.39±0.73mm~2)都增大,溃疡容积愈合率(-30±9.4％)和面积愈合率(-50±2.1％)显著降低;甲轻亢组溃疡容积(4.75±0.88mm~3)和面积(4.05±0.93mm~2)都减小,但无统计学意义,溃疡容积愈合率(37±3.8％)和面积愈合率(49±3.2％)显著升高;甲亢组溃疡容积(4.88±0.90mm~3)和面积(5.16±0.74mm~2)与对照组的接近,溃疡容积愈合率(28±1.1％)和面积愈合率(10±1.9％)升高,但无统计学意义。这些发现提示:1.甲状腺素是胃溃疡愈合所必需的激素,甲低时胃溃疡愈合速度减慢;2.小剂量甲状腺素可促进胃溃疡的愈合。更多还原

【Abstract】 Using a quantitative method, the healing of the experimental gastric ulcer in rats was studied in various states of thyroid function. Rats were made hypothyroid by ingestion of thiouracil （0.1％ solution in drinking water for 10 days）. Rats were made slightly hyperthyroid by ingestion of thiouracil and simultaneous administration of T₄ （3μg/100 g/day,ip） for 10 days. Rats were made hyperthyroid by administration of excess T₄ （10μg/100 g/day, ip） for 10 days. The normal rats served as controls. In all of these rats, gastric ulcer was induced by injecting a small quantity of glacial acetic acid into the submucosa of the stomach after laparotomy under aseptic conditions. After operation the rats in four groups were given those drugs as above respectively for 10 days. The volume （7.71±0.52mm³’ 5.5±0.78 mm³ for control） and area （8.29±0.90mm²; 4.39±0.73mm² for control） of gastric ulcer increased in the rats with hypothyroidism. The healing rate of gastric ulcer retarded （-30±9.4％ for volume healing rate, -50±2.1％ for area healing rate）. The volume （4.75±0.88mm³） and area （4.05±0.93mm²） of gastric ulcer decreased in the rats with slight hyperthyroidism, and the healing rate of gastric ulcer accelerated （37±3.8％ for volume healing rate, 49±3.2％ for area healing rate）. The volume （4.88±0.90mm³） and area （6.16±0.74mm²） and the healing rates of gastric ulcer in the rats with hyperthyroidism were similar as those of control. These findings suggested that （1） thyroxine is necessary for healing of the experimental gastric ulcer in rats and （2） thyroxine seem to accelerate healing of the experimental gastric ulcer in rats.更多还原