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胱氨酸对家兔动脉粥样硬化发生的影响

EFFECT OF CYSTINE ON ATHEROSCLEROSIS OF RABBITS

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【作者】 谷凤岐张家芳刘继周

【Author】 Gu Fengqi et al (Department of Biochemistry)

【机构】 济宁医学院生物化学教研室济宁医学院组织胚胎学教研室济宁医学院病理解剖学教研室

【摘要】 实验选5~6个月的家兔30只,随机分为实验组(喂胱氨酸和胆固醇)和对照组(喂胆固醇),饲养113天杀死,取主动脉和心脏切片,用组织学和组化方法染色。结果表明实验组和对照组血胆固醇都升高,实验组血硫升高,直接破坏动脉壁,且胆固醇和甘油三脂易沉积于主动脉内膜中,同时冠状动脉肌支发生粥样硬化病变,实验组多于对照组,二者差异非常显著,说明胱氨酸有促进主动脉和冠状动脉肌支粥样硬化早期病变的作用。

【Abstract】 The experiment took 30 rabbits of five to six months,whchi were separated into an experimental group(fed with cystine and cholesterol)and a contratest grop(fed with cholesterol).After 113 days,the rabbits were killed and sections of aorta and heart were taken and stained by the method of histology and histochemistryre. The results show that the cholesterol in the blood of each rabbit in the two groups has risen.But in the experimental group,the thiam in in some rabbits’ blood had risen,which may directly wear the walls of the artery.Moreover,the cholesterol and triglyceride are easily deposited in the tunica intima of the aorta and,at the same time, atherosclerosis has been shaped in the muscular branches of coronara arteries.There are more rabbits with above changes in the experimently group than in the contratest one.Differences between them are remark able.That show cystine may promote an early atherosclerosis of aorta and muscular branches of coronary artery.

【关键词】 胱氨酸主动脉冠状功脉胆固醇
【Key words】 CystineAortaCoronary arteryCholesterol
  • 【文献出处】 济宁医学院学报 ,Journal of Jining Medical College , 编辑部邮箱 ,1988年01期
  • 【被引频次】1
  • 【下载频次】10
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