【摘要】 高密度脂蛋白（HDL）的胆固醇脂（CE）转移给极低密度脂蛋白（VLDL）、低密度蛋白（LDL）是逆向的胆固醇转移（Reverse Cholesterol transport）中的重要一步。胆固醇转移率（RCT₁ Rate of Cholesterol Transfer）表示HDL将CE转运给VLDL的速率mg/hr·100ml。尿毒症及慢性肾疾患患者的RCT显著地低于正常人（P<0.001）,RCT的下降不是由于年龄差别,也不仅足由于患者的HDL-ch下降所致。更多还原

【Abstract】 Cholesteryl esters in high density lipoproteins (HDL) is transferred to very low density lipoproteins (VLDL) and low density lipoproteins (LDL) , the re_ distribution of cholesterol from HDL to VLDL is considered a crucial step in the reverse cholesterol transport pathway. A defect in cholesterol transport was detected in patients with uremia and degenerative nephritides when the rate of cholesterol transfer (RCT) mg/hr·100ml from HDL to VLDL and LDL was compared with that in controls (p<0.001). The decreased RCT of the patients could not be completely accounted for by their decreased HDL cholesterol levels or different ages.更多还原