【摘要】 本文报告用 MNNG(N—甲基—N′—硝基—N—亚硝基胍.简称 MNNG)溶诱液(500ug/ml)采取“连续定量限期”法给药诱发大白鼠腺胃胃癌病理形态学动态观察结果。在第84、168、217天分别诱发出粘膜内癌、早期浸润癌及浸润癌与多灶性癌,获得较高诱癌率(47/80只),表明给药时间以7～14个月为宜。47例胃癌共97个癌灶,大部分位于胃窦。粘膜混浊、灰白或灰黄是腺癌的最早期改变。组织学类型以高分化腺癌最多,其次为粘液腺癌、混合型癌、印戒细胞癌。研究表明,癌前病变为腺瘤性增生与不典型增生,而非肠化,癌变过程为粘膜糜烂→再生性增生(腺瘤性增生不典型增生)→早期癌(粘膜内癌与早期润癌)→浸润癌。更多还原

【Abstract】 In this paper,seguential pathomorphological study of gastric carein- oma of glandular stomach in wistar rats induced by administration of MNNG(500ug/ml)is report.Intramucosal carcinoma,early infiltrating carcinoma and infiltrating carcinoma with multiple foci carcinoma were discovered in 84th,168th,and 217th daysrespectively.And 47 case adenoc- arcinoma of 80 rats were obtained,that were seen 97 carcinomatous foci, that most of them were distributed in the gastric antrum.Cloudy、grey o grey-yellow mucosa might be the most early changes of gastric carcinoma. Histological types were mostly well-differentiated adenocarcinoma(69/ 97).and them mucoid carcinoma(17/97),mixed type carcinoma(8/97) and signet-ring celt carcinoma(3/97).The result suggested that the adencmatous proliferation and dysplasia of the gastric glands may be the precarcerous lesions,But no intestinal mataplasia.And the seguential pathomorphologic change may be a continued coursr including mucosal erosion→regenerative hyperplasia adenomatous proliferation dysplasia early carci- noma(intramucosal carcinoma and early infiltrating carcinoma)→infiltr- ating carcinoma.更多还原